Öz
Kaynakça
- Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
- Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com
Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest
Öz
The coronavirus, known as severe acute respiratory syndrome (SARS-CoV-2), is accountable for the global epidemic disease COVID-19. The effective treatment of this disease is still unknown and there is an emergent need to use all resources to find the effective medication. The use of off-label natural medicinal compounds may be effective remedy for this scourge. Towards the investigation of effective inhibitor of 3CL protease, we studied the in silico interaction of the selected compounds of Mesua Ferrae Linn, an Asian medicinal plant. The studied compounds have shown excellent inhibition properties. The timber extracts, Mesuabixanthone-B (∆Gbind = -15.51 kcal/mol) and Mesuferrol-B (∆Gbind = -14.32 kcal/mol) are among the exciting hits on 6LU7. The in silico prediction of toxicities of the extracts are also promising. The further lab research is necessary to testify these drug candidates against COVID-19 infections.
Anahtar Kelimeler
Kaynakça
- Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
- Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Biyokimya ve Hücre Biyolojisi (Diğer) |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Mayıs 2021 |
| Gönderilme Tarihi | 28 Aralık 2020 |
| Kabul Tarihi | 9 Nisan 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 2 Sayı: 2 |
Turkish Journal of Science and Health (TFSD)
E-mail: tfsdjournal@gmail.com
Bu eser Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.