Öz
Manyetik nanopartiküller birçok kullanım alanına sahip olup manyetik olarak saflaştırılabilirlik, geniş yüzey alanı, manyetik hedefleme, yüzey modifikasyonunda kolaylık gibi avantajları sayesinde son yıllarda ilgi çeken malzemelerden biri olmuştur. Gözenekli malzemeler ise, daha fazla açığa çıkan katalitik bölgelere ve geliştirilmiş yüzey işlevselliğine sahip bir malzemeye eldesine imkan sağlar. Ayrıca mezogözenekli Fe3O4 nanotüpleri sahip olduğu eşsiz yapısı sayesinde, bağlanacak ilaç hem destek malzemesinin dış yüzeyine hem de mezogözeneklerine girerek paketlenmiş yapıya benzer bir şekilde bağlanacaktır. Bu sayede hem ilacın yarılanma ömrünü uzatacak hem de parçalanma ürünlerinin hızlı serbestleşmesini engelleyeceğinden ilacın kontrollü bir şekilde taşınabilmesi için ideal bir sistem oluşturacaktır. Bu makalede ilaç hedeflemede kullanılmak üzere mezogözenekli Fe3O4 nanotüp sentezi yapılmıştır. Bu amaçla öncelikle mezogözenekli SiO2 üretimi yapılarak Fe3O4 üretiminde şablon olarak kullanılmıştır. Üretilen mezogözenekli SiO2 yüzeyine, [Fe(NH2CONH2)6](NO3)3 kompleksi kullanılarak Fe3O4 indirgenmiş ve ardından yapıdaki SiO2 liç edilerek mezogözenekli Fe3O4 nanotüp hazırlanmıştır. Hazırlanan malzemeler FESEM, FT-IR, BET, XRD ve TG yöntemleri ile analiz edilmiştir.
Anahtar Kelimeler
mezogözenekli SiO2 Mezogözenekli Fe3O4 nanotüp üre sol-jel yöntemi
Destekleyen Kurum
TÜBİTAK-BİDEB-2218
Proje Numarası
118C475
Teşekkür
Bu çalışma TÜBİTAK-BİDEB-2218 Yurt İçi Doktora Sonrası Araştırma Burs Programı kapsamında 118C475 numaralı proje ile desteklenmiştir. Desteklerinden dolayı TÜBİTAK’a sonsuz teşekkür ederiz.
Kaynakça
- Alivisatos A.P. Semiconductor Clusters, Nanocrystals, and Quantum Dots. Science, 1996; 271:933-937.
- Alkyne J. F., Fingerhut A. G., Rand R. W. Magnetic probe for the stereotactic thrombosis of intracranial aneurysms. Journal Neurol Neurosurg Psychiatry, 1967; 30:159-162.
- Asuha S., Wan H.L., Zhao S., Deligeer W., Wu H.Y., Song L., Tegus O. Water-soluble, mesoporous Fe3O4: synthesis, characterization, and properties. Ceramics International, 2012; 38: 6579–6584.
- Asuha S., Zhao S., Jin X.H., Hai M.M., Bao H.P. Effects of synthetic routes of Fe–urea complex on the synthesis of g-Fe2O3 nanopowder. Applied Surface Science, 2009; 255:8897-8901.
- Charitidis C.A., Georgiou P., Koklioti M.A., Trompeta A.F., Markakis V. Manufacturing nanomaterials: from research to industry. Manufacturing Review, 2014; 1: 19.
- Chen T. T., Zhou G. Y., Zhu Q. A., Liu X. A., Ha T. Z., Kelley J. L., Kao R.L., Williams D.L., Chuanfu L. Overexpression of vascular endothelial growth factor 165 (VEGF(165)) protects cardiomyocytes against doxorubicin-induced apoptosis. Journal of Chemotherapy, 2010; 22: 402–406.
- Cheng K., Peng S., Xu C. J., Sun S. H. Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin. Journal of the American Chemical Society, 2009;131:10637–10644.
- Deng J., Feng S.F., Zhang K., Li J., Wang H., Zhang T., Ma X. Heterogeneous activation of peroxymonosulfate using ordered mesoporous Co3O4 for the degradation of chloramphenicol at neutral pH. Chemical Engineering Journal, 2017; 308: 505–515.
- Dubey, R. S., Rajesh, Y. B. R. D., More, M. A. Synthesis and Characterization of SiO2 Nanoparticles via Sol-gel Method for Industrial Applications. Materials Today: Proceedings, 2015; 2: 3575-3579.
- Hilal S. K., Michelsen W. J., Driller J., Leonard E. Magnetically guided devices for vascular exploration and treatment. Radiology, 1974;113: 529-540.
- Jiao F., Harrison A., Jumas J.C., Chadwick A.V., Kockelmann W., Bruce P.G. Ordered Mesoporous Fe2O3 with Crystalline Walls. Journal of the American Chemical Society, 2006; 128: 5468–5474.
- Karatutlu A., Barhoum A., Sapelkin A. Liquid-phase synthesis of nanoparticles and nanostructured materials. Emerging Applications of Nanoparticles and Architecture Nanostructures, 2018; 1-28.
- Kleinstreuer C., Feng Y., Childress E. Drug-targeting methodologies with applications: A review. World Journal of Clinical Cases, 2014; 16:742-756.
- Manivannan, M., Rajendran, S. Investigation of inhibitive action of Urea-Zn2 system in the corrosion control of carbon steel in sea water. International Journal of Science Education, 2011; 2: 445-451.
- McBain S. C., Yiu H. H., Dobson J. Magnetic nanoparticles for gene and drug delivery. International Journal of Nanomedicine, 2008; 3:169-180.
- Ozkaya T., Toprak M.S., Baykal A., Kavas H., Köseoğlu Y.,Aktaş B. Synthesis of Fe3O4 nanoparticles at 100 °C and its magnetic characterization. Journal of Alloys and Compounds, 2009; 472:18-23.
- Piao Y.Z., Kim J., Na H.B., Kim D., Baek J.S., Ko M.K., Lee J.H., Shokouhimehr M., Hyeon T. Wrap–bake–peel process for nanostructural transformation from β-FeOOH nanorods to biocompatible iron oxide nanocapsules. Nature Materials, 2008; 7: 242–247.
- Rapoport N. Y., Herron J. N., Pitt W. G., Pitina L. Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake. Journal of Controlled Release, 1999; 58: 153-162.
- Rapoport N., Marin A. P., Timoshin A. A. Effect of a polymeric surfactant on electron transport in HL-60 cells. Archives of Biochemistry and Biophysics, 2000; 384: 100-108.
- Rapoport N., Marin A., Luo Y., Prestwich G. D., Muniruzzaman M. D. Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization. Journal of Pharmaceutical Sciences, 2002; 91:157-170.
- Rapoport N., Marin A., Muniruzzaman M., Christensen D.A. Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant Cells: Effects of Pluronic Micelles and Ultrasound. ACS Symposium Series. American Chemical Society, 2003; 7: 85-100.
- Rapoport N. Stabilization and activation of Pluronic micelles for tumor-targeted drug delivery. Biointerfaces, 1999; 16: 93-111.
- Senyei A., Widder K.,Czerlinski G. Magnetic guidance of drug‐carrying microspheres. Journal of Applied Physics, 1978; 49: 3578-3583.
- Tadic M., Panjan M., Damnjanovic V., Milosevic I. Magnetic properties of hematite (α-Fe2O3) nanoparticles prepared by hydrothermal synthesis method. Applied Surface Science, 2014; 320: 183-187.
- Wang Y., Xia Y. Bottom-Up and Top-Down Approaches to the Synthesis of Monodispersed Spherical Colloids of Low Melting-Point Metals. Nano Letters, 2004; 4 (10): 2047–2050.
- Wang Y.,Yao S., Crocker M., Zhu X., Chen B., Xie J., Shi C., Ma D. An energy-efficient catalytic process for the tandem removal of formaldehyde and benzene by metal/HZSM-5 catalysts. Catalysis Science & Technology, 2015; 5: 4968–4972.
- Widder K. J., Marino P. A., Morris R. M., Howard D. P., Poore G. A., Senyei A. E. Selective targeting of magnetic albumin microspheres to the Yoshida sarcoma: ultrastructural evaluation of microsphere disposition. European Journal of Cancer and Clinical Oncology, 1983; 19:141-147.
- Xu J., Ouyang L., Mao W., Yang X. J., Xu X. C., Su J. J., Zhuang T. Z., Li H., Han Y. F. Operando and Kinetic Study of Low-Temperature, Lean-Burn Methane Combustion over a Pd/γ-Al2O3 Catalyst. ACS Catalysis, 2012; 2: 261–269.
- Yadav T.P., Yadav Y.M., Singh D.P. Mechanical Milling: a Top Down Approach for the Synthesis of Nanomaterials and Nanocomposites. Nanoscience and Nanotechnology, 2012; 2(3):22-48.
- Zhang L., Liua T., Chen Y. Magnetic Conducting Polymer/Mesoporous SiO2 Yolk/Shell Nanomaterials: Multifunctional Nanocarriers for Controlled Release of Doxorubicin. RSC Advances, 2016; 6: 8572-8579.
- Zhao J., Shu Y., Zhang P. Solid-state CTAB-assisted synthesis of mesoporous Fe3O4 and Au@Fe3O4 by mechanochemistry. Chinese Journal of Catalysis, 2019; 40:1078-1084.
Öz
Magnetic nanoparticles have many uses and have become one of the materials that have attracted attention in recent years, thanks to their advantages such as magnetic purification, large surface area, magnetic targeting, and ease of surface modification. Porous materials, on the other hand, allow for a material with more exposed catalytic sites and improved surface functionality. In addition, thanks to the unique structure of mesoporous Fe3O4 nanotubes, the drug to be bound will enter both the outer surface of the support material and the mesopores and bind in a similar way to the packaged structure. In this way, it will create an ideal system for the controlled transport of the drug, as it will both prolong the half-life of the drug and prevent the rapid release of degradation products. In this article, mesoporous Fe3O4 nanotubes were synthesized to be used in drug targeting. For this purpose, firstly mesoporous SiO2 was produced and used as a template in Fe3O4 production. Fe3O4 was reduced to the produced mesoporous SiO2 surface by using [Fe(NH2CONH2)6](NO3)3 complex and then mesoporous Fe3O4 nanotube was prepared by leaching SiO2 in the structure. The prepared materials were analyzed by FESEM, FT-IR, BET, XRD and TG methods.
Anahtar Kelimeler
Mesoporous SiO2 Mesoporous Fe3O4 nanotubes Sol-gel method urea
Proje Numarası
118C475
Kaynakça
- Alivisatos A.P. Semiconductor Clusters, Nanocrystals, and Quantum Dots. Science, 1996; 271:933-937.
- Alkyne J. F., Fingerhut A. G., Rand R. W. Magnetic probe for the stereotactic thrombosis of intracranial aneurysms. Journal Neurol Neurosurg Psychiatry, 1967; 30:159-162.
- Asuha S., Wan H.L., Zhao S., Deligeer W., Wu H.Y., Song L., Tegus O. Water-soluble, mesoporous Fe3O4: synthesis, characterization, and properties. Ceramics International, 2012; 38: 6579–6584.
- Asuha S., Zhao S., Jin X.H., Hai M.M., Bao H.P. Effects of synthetic routes of Fe–urea complex on the synthesis of g-Fe2O3 nanopowder. Applied Surface Science, 2009; 255:8897-8901.
- Charitidis C.A., Georgiou P., Koklioti M.A., Trompeta A.F., Markakis V. Manufacturing nanomaterials: from research to industry. Manufacturing Review, 2014; 1: 19.
- Chen T. T., Zhou G. Y., Zhu Q. A., Liu X. A., Ha T. Z., Kelley J. L., Kao R.L., Williams D.L., Chuanfu L. Overexpression of vascular endothelial growth factor 165 (VEGF(165)) protects cardiomyocytes against doxorubicin-induced apoptosis. Journal of Chemotherapy, 2010; 22: 402–406.
- Cheng K., Peng S., Xu C. J., Sun S. H. Porous Hollow Fe3O4 Nanoparticles for Targeted Delivery and Controlled Release of Cisplatin. Journal of the American Chemical Society, 2009;131:10637–10644.
- Deng J., Feng S.F., Zhang K., Li J., Wang H., Zhang T., Ma X. Heterogeneous activation of peroxymonosulfate using ordered mesoporous Co3O4 for the degradation of chloramphenicol at neutral pH. Chemical Engineering Journal, 2017; 308: 505–515.
- Dubey, R. S., Rajesh, Y. B. R. D., More, M. A. Synthesis and Characterization of SiO2 Nanoparticles via Sol-gel Method for Industrial Applications. Materials Today: Proceedings, 2015; 2: 3575-3579.
- Hilal S. K., Michelsen W. J., Driller J., Leonard E. Magnetically guided devices for vascular exploration and treatment. Radiology, 1974;113: 529-540.
- Jiao F., Harrison A., Jumas J.C., Chadwick A.V., Kockelmann W., Bruce P.G. Ordered Mesoporous Fe2O3 with Crystalline Walls. Journal of the American Chemical Society, 2006; 128: 5468–5474.
- Karatutlu A., Barhoum A., Sapelkin A. Liquid-phase synthesis of nanoparticles and nanostructured materials. Emerging Applications of Nanoparticles and Architecture Nanostructures, 2018; 1-28.
- Kleinstreuer C., Feng Y., Childress E. Drug-targeting methodologies with applications: A review. World Journal of Clinical Cases, 2014; 16:742-756.
- Manivannan, M., Rajendran, S. Investigation of inhibitive action of Urea-Zn2 system in the corrosion control of carbon steel in sea water. International Journal of Science Education, 2011; 2: 445-451.
- McBain S. C., Yiu H. H., Dobson J. Magnetic nanoparticles for gene and drug delivery. International Journal of Nanomedicine, 2008; 3:169-180.
- Ozkaya T., Toprak M.S., Baykal A., Kavas H., Köseoğlu Y.,Aktaş B. Synthesis of Fe3O4 nanoparticles at 100 °C and its magnetic characterization. Journal of Alloys and Compounds, 2009; 472:18-23.
- Piao Y.Z., Kim J., Na H.B., Kim D., Baek J.S., Ko M.K., Lee J.H., Shokouhimehr M., Hyeon T. Wrap–bake–peel process for nanostructural transformation from β-FeOOH nanorods to biocompatible iron oxide nanocapsules. Nature Materials, 2008; 7: 242–247.
- Rapoport N. Y., Herron J. N., Pitt W. G., Pitina L. Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake. Journal of Controlled Release, 1999; 58: 153-162.
- Rapoport N., Marin A. P., Timoshin A. A. Effect of a polymeric surfactant on electron transport in HL-60 cells. Archives of Biochemistry and Biophysics, 2000; 384: 100-108.
- Rapoport N., Marin A., Luo Y., Prestwich G. D., Muniruzzaman M. D. Intracellular uptake and trafficking of Pluronic micelles in drug-sensitive and MDR cells: effect on the intracellular drug localization. Journal of Pharmaceutical Sciences, 2002; 91:157-170.
- Rapoport N., Marin A., Muniruzzaman M., Christensen D.A. Controlled Drug Delivery to Drug-Sensitive and Multidrug Resistant Cells: Effects of Pluronic Micelles and Ultrasound. ACS Symposium Series. American Chemical Society, 2003; 7: 85-100.
- Rapoport N. Stabilization and activation of Pluronic micelles for tumor-targeted drug delivery. Biointerfaces, 1999; 16: 93-111.
- Senyei A., Widder K.,Czerlinski G. Magnetic guidance of drug‐carrying microspheres. Journal of Applied Physics, 1978; 49: 3578-3583.
- Tadic M., Panjan M., Damnjanovic V., Milosevic I. Magnetic properties of hematite (α-Fe2O3) nanoparticles prepared by hydrothermal synthesis method. Applied Surface Science, 2014; 320: 183-187.
- Wang Y., Xia Y. Bottom-Up and Top-Down Approaches to the Synthesis of Monodispersed Spherical Colloids of Low Melting-Point Metals. Nano Letters, 2004; 4 (10): 2047–2050.
- Wang Y.,Yao S., Crocker M., Zhu X., Chen B., Xie J., Shi C., Ma D. An energy-efficient catalytic process for the tandem removal of formaldehyde and benzene by metal/HZSM-5 catalysts. Catalysis Science & Technology, 2015; 5: 4968–4972.
- Widder K. J., Marino P. A., Morris R. M., Howard D. P., Poore G. A., Senyei A. E. Selective targeting of magnetic albumin microspheres to the Yoshida sarcoma: ultrastructural evaluation of microsphere disposition. European Journal of Cancer and Clinical Oncology, 1983; 19:141-147.
- Xu J., Ouyang L., Mao W., Yang X. J., Xu X. C., Su J. J., Zhuang T. Z., Li H., Han Y. F. Operando and Kinetic Study of Low-Temperature, Lean-Burn Methane Combustion over a Pd/γ-Al2O3 Catalyst. ACS Catalysis, 2012; 2: 261–269.
- Yadav T.P., Yadav Y.M., Singh D.P. Mechanical Milling: a Top Down Approach for the Synthesis of Nanomaterials and Nanocomposites. Nanoscience and Nanotechnology, 2012; 2(3):22-48.
- Zhang L., Liua T., Chen Y. Magnetic Conducting Polymer/Mesoporous SiO2 Yolk/Shell Nanomaterials: Multifunctional Nanocarriers for Controlled Release of Doxorubicin. RSC Advances, 2016; 6: 8572-8579.
- Zhao J., Shu Y., Zhang P. Solid-state CTAB-assisted synthesis of mesoporous Fe3O4 and Au@Fe3O4 by mechanochemistry. Chinese Journal of Catalysis, 2019; 40:1078-1084.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Kimya Mühendisliği, Malzeme Üretim Teknolojileri |
| Bölüm | Araştırma Makaleleri (RESEARCH ARTICLES) |
| Yazarlar | |
| Proje Numarası | 118C475 |
| Yayımlanma Tarihi | 5 Temmuz 2023 |
| Gönderilme Tarihi | 17 Mayıs 2022 |
| Kabul Tarihi | 16 Ocak 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 6 Sayı: 2 |
Kaynak Göster
* Uluslararası Hakemli Dergi (International Peer Reviewed Journal)
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*Dergi açık erişimli bir dergidir.
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