Klinik Araştırma
Yıl 2023,
Cilt: 51 Sayı: 4, 381 - 388, 07.11.2023
Öz
Destekleyen Kurum
Gazi Üniversitesi
Proje Numarası
095 nolu BAP projesi
Kaynakça
- Z. Chegini, M. Didehdar, A. Khoshbayan, J. Karami, M. Yousefimashouf and A. Shariati, The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis, Cell Communication and Signaling, (2022) 20-29.
- M.S. Rha, S.W. Kim, D.Y. Chang, J.K. Lee, J. Kim, S.H. Park, R. Khalmuratova, H.S. Lim, K.M. Eun, S.N. Hong, Superantigen-related TH2 CD4+ T cells in nonasthmatic chronic rhinosinusitis with nasal polyps, J. Allergy Clin. Immunol., 145 (2020) 1378-1388.
- W. Ivy, N. Maina & Neil, Patel & Noam, A. Cohen, Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis, Current Otorhinolaryngology Reports, 6 (2018) 253–262.
- R.P. Schleimer, A. Kato, A. Peters, D.B. Conley, Epithelium, inflammation, and immunity in the upper airways of humans; studies in chronic rhinosinusitis, Proc. Am. Thorac. Soc., 6 (2009) 288–294.
- R.G. Slavin, Sinusitis: Viral, bacterial, or fungal and what is the role of staph?, Allergy Asthma Proc.,27 (2006) 447–450.
- T. Delemarre, N. De Ruyck, G. Holtappels, C. Bachert, E. Gevaert, Unravellingthe expression of interleukin-9 in chronic rhinosinusitis: a possible role for Staphylococcus aureus, Clin. Transl. Allergy. 10 (2020) 1–4.
- N. Zhang, P. Gevaert, T. van Zele, N.C. Perez et al, An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis, Rhinology, 43 (2005) 162–168.
- C. Bachert, B. Marple, R. J. Schlosser, C. Hopkins, R. P. Schleimer, B. N. Lambrecht, B. M. Bröker, T. Laidlaw and Woo- Jung Song, Adult chronic rhinosinusitis, Nature reviews Disease Primers Article citation, 6 (2020) 86.
- C. Bachert et al., Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge, Eur. Respir. J., 55 (2020) 190-192.
- Y. Chan, F.A. Kuhn, An update on the classifications, diagnosis, and treatment of rhinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 17 (2009) 204–208.
- Mde L. da Cunha, R.A. Calsolari, J.P. Júnior, Detection of enterotoxin and toxic shock syndrome toxin 1 genes in staphylococcus, with emphasis on coagulase-negative staphylococci, Microbiol. Immunol., 51 (2007) 381–390.
- L.M. el Fiky, N. Khamis, Bel D. Mostafa, A.M. Adly, Staphylococcal infection and toxin production in chronic rhinosinusitis, Am. J. Rhinol. Allergy, 23 (2009) 264–267.
- M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus, BMC Microbiol., 9 (2009) 52.
- J. Patou, P. Gevaert, T. van Zele, G. Holtappels et al, Staphylococcus aureus enterotoxin b, protein a and lipoteichoic acid stimulations in nasal polyps, J. Allergy Clin. Immunol., 121 (2008) 110–115.
- A.N. Pearlman, D.B. Conley, Review of current guidelines related to the diagnosis and treatment of rinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 16 (2009) 226–230.
- T. Proft, J. D. Fraser, Bacterial superantigens, Clin. Exp. Immunol., 133 (2003) 299–306.
- S.Tuff, S. Haeryfar, J. McCormick, Manipulation of innate and adaptive immunity by staphylococcal superantigens, Pathogens, 7 (2018) 53.
- B.Fleischer, H. Schrezenmeier, T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells, J. Exp. Med., 167 (1988) 1697–1707.
- M. Yarıktas, M. Demirci, F. Döner, M. Tuz et al, Microbiologic findings of sinusitis by a novel method for obtaining culture, Diagn. Microbiol. Infect. Dis., 58 (2007) 49–52.
- W.E. Kloos, Natural populations of the genus Staphyloccus. Annu. Rev. Microbiol., 34 (1980) 559–592.
- M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa, et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus. BMC Microbiol., 9 (2009) 52.
- Y. Lee, B. Moon, J. Park, H. Chang, et al, Expression of enterotoxin genes in Staphylococcus aureus isolates based on mRNA analysis, Microbiol. Biotechnol., 17 (2007) 461–467.
- G. Raymond, R. Slavin, SL. Spector, I.L. Bernstein, The diagnosis and management of sinusitis: A practice parameter update, J. Allergy. Clin. Immunol. 116 (2005) 13–47.
- M. Wang, P. Shi, B. Chen, H. Zhang. et al, The role of superantigens in chronic rhinosinusitis with nasal polyps, ORL J. Otorhinolaryngol. Relat. Spec., 70 (2007) 97–103.
- F. Heymans, A. Fischer, N.W. Stow, M. Girard, et al, screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposis, PLoS One (2005).
- K.A. Seiberling, D.B. Conley, A. Tripathi, L.C. Grammer, et al, Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps. Laryngoscope 115 (2005) 1580–1585.
- T. Van Zele, M. Vaneechoutte, G. Holtappels, P. Gevaert et al, Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients, Am. J. Rhinol. 22 (2008) 223–227.
- M. Laudien, S.D. Gadola, R. Podschun, J. Hedderich et al, Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener s granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps, Clin. Exp. Rheumatol. 28 (2010) 51–55.
- A. Niederfuhr, H. Kirsche, T. Deutschle, S. Poppert, et al, Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis. Allergy 63 (2008) 1359–1367.
- M. Burian, C. Wolz, C. Goerke, Regulatory adaptation of Staphylococcus aureus during nasal colonization of humans, PLoS One (2010).
Assessment of Staphylococcal toxins acting as superantigens in different nasal specimens in the etiology of chronic rhinosinusitis
Öz
The mechanism of development of chronic rhinosinusitis(CRS) is not fully known. However, bacteria are thought to play an important role in this clinic. It has been suggested that toxins with superantigen(SAgs) properties produced by one of these bacteria, Staphylococcus aureus(S.aureus), play a role in the development of inflammation associated with sinusitis. In this study, S.aureus was isolated by taking endoscopic sinus biopsy samples and nasal swab samples from patients with CRS and the control group. It was aimed to examine the frequency of S.aureus presence in the samples taken, the presence of toxin genes showing superantigen quality in these isolated bacteria, and to evaluate the roles of these parameters in the development of CRS. More S.aureus was isolated in the samples taken from patients with CRS than in the control group. The isolated S.aureus samples were analysed by real-time PCR method. The presence of enterotoxin A, B, C and D genes in the S.aureus samples isolated from the patient group were found at the rates of 54%, 32%, 16% and 16%, respectively, while these rates were 46%, 24%, 14% and 14% in the control group. The Toxic Shock Syndrome Toxin-1(TSST-1) gene was detected in 20% of the samples isolated from the patient and 46% in the control group bacteria. The fact that S.aureus was isolated in 20% of the patients shows that this bacterium is not necessary for CRS. The frequency of superantigen toxin genes in S.aureus isolates shows that these toxins are not necessary for the development of the disease.
Anahtar Kelimeler
S. aureus enterotoxin toxic shock syndrome toxin-1 chronic rhinosinusitis
Proje Numarası
095 nolu BAP projesi
Kaynakça
- Z. Chegini, M. Didehdar, A. Khoshbayan, J. Karami, M. Yousefimashouf and A. Shariati, The role of Staphylococcus aureus enterotoxin B in chronic rhinosinusitis with nasal polyposis, Cell Communication and Signaling, (2022) 20-29.
- M.S. Rha, S.W. Kim, D.Y. Chang, J.K. Lee, J. Kim, S.H. Park, R. Khalmuratova, H.S. Lim, K.M. Eun, S.N. Hong, Superantigen-related TH2 CD4+ T cells in nonasthmatic chronic rhinosinusitis with nasal polyps, J. Allergy Clin. Immunol., 145 (2020) 1378-1388.
- W. Ivy, N. Maina & Neil, Patel & Noam, A. Cohen, Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis, Current Otorhinolaryngology Reports, 6 (2018) 253–262.
- R.P. Schleimer, A. Kato, A. Peters, D.B. Conley, Epithelium, inflammation, and immunity in the upper airways of humans; studies in chronic rhinosinusitis, Proc. Am. Thorac. Soc., 6 (2009) 288–294.
- R.G. Slavin, Sinusitis: Viral, bacterial, or fungal and what is the role of staph?, Allergy Asthma Proc.,27 (2006) 447–450.
- T. Delemarre, N. De Ruyck, G. Holtappels, C. Bachert, E. Gevaert, Unravellingthe expression of interleukin-9 in chronic rhinosinusitis: a possible role for Staphylococcus aureus, Clin. Transl. Allergy. 10 (2020) 1–4.
- N. Zhang, P. Gevaert, T. van Zele, N.C. Perez et al, An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis, Rhinology, 43 (2005) 162–168.
- C. Bachert, B. Marple, R. J. Schlosser, C. Hopkins, R. P. Schleimer, B. N. Lambrecht, B. M. Bröker, T. Laidlaw and Woo- Jung Song, Adult chronic rhinosinusitis, Nature reviews Disease Primers Article citation, 6 (2020) 86.
- C. Bachert et al., Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge, Eur. Respir. J., 55 (2020) 190-192.
- Y. Chan, F.A. Kuhn, An update on the classifications, diagnosis, and treatment of rhinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 17 (2009) 204–208.
- Mde L. da Cunha, R.A. Calsolari, J.P. Júnior, Detection of enterotoxin and toxic shock syndrome toxin 1 genes in staphylococcus, with emphasis on coagulase-negative staphylococci, Microbiol. Immunol., 51 (2007) 381–390.
- L.M. el Fiky, N. Khamis, Bel D. Mostafa, A.M. Adly, Staphylococcal infection and toxin production in chronic rhinosinusitis, Am. J. Rhinol. Allergy, 23 (2009) 264–267.
- M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus, BMC Microbiol., 9 (2009) 52.
- J. Patou, P. Gevaert, T. van Zele, G. Holtappels et al, Staphylococcus aureus enterotoxin b, protein a and lipoteichoic acid stimulations in nasal polyps, J. Allergy Clin. Immunol., 121 (2008) 110–115.
- A.N. Pearlman, D.B. Conley, Review of current guidelines related to the diagnosis and treatment of rinosinusitis, Curr. Opin. Otolaryngol. Head Neck Surg., 16 (2009) 226–230.
- T. Proft, J. D. Fraser, Bacterial superantigens, Clin. Exp. Immunol., 133 (2003) 299–306.
- S.Tuff, S. Haeryfar, J. McCormick, Manipulation of innate and adaptive immunity by staphylococcal superantigens, Pathogens, 7 (2018) 53.
- B.Fleischer, H. Schrezenmeier, T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells, J. Exp. Med., 167 (1988) 1697–1707.
- M. Yarıktas, M. Demirci, F. Döner, M. Tuz et al, Microbiologic findings of sinusitis by a novel method for obtaining culture, Diagn. Microbiol. Infect. Dis., 58 (2007) 49–52.
- W.E. Kloos, Natural populations of the genus Staphyloccus. Annu. Rev. Microbiol., 34 (1980) 559–592.
- M. Nagao, A. Okamoto, K. Yamada, T. Hasegawa, et al, Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus. BMC Microbiol., 9 (2009) 52.
- Y. Lee, B. Moon, J. Park, H. Chang, et al, Expression of enterotoxin genes in Staphylococcus aureus isolates based on mRNA analysis, Microbiol. Biotechnol., 17 (2007) 461–467.
- G. Raymond, R. Slavin, SL. Spector, I.L. Bernstein, The diagnosis and management of sinusitis: A practice parameter update, J. Allergy. Clin. Immunol. 116 (2005) 13–47.
- M. Wang, P. Shi, B. Chen, H. Zhang. et al, The role of superantigens in chronic rhinosinusitis with nasal polyps, ORL J. Otorhinolaryngol. Relat. Spec., 70 (2007) 97–103.
- F. Heymans, A. Fischer, N.W. Stow, M. Girard, et al, screening for staphylococcal superantigen genes shows no correlation with the presence or the severity of chronic rhinosinusitis and nasal polyposis, PLoS One (2005).
- K.A. Seiberling, D.B. Conley, A. Tripathi, L.C. Grammer, et al, Superantigens and chronic rhinosinusitis: detection of staphylococcal exotoxins in nasal polyps. Laryngoscope 115 (2005) 1580–1585.
- T. Van Zele, M. Vaneechoutte, G. Holtappels, P. Gevaert et al, Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients, Am. J. Rhinol. 22 (2008) 223–227.
- M. Laudien, S.D. Gadola, R. Podschun, J. Hedderich et al, Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener s granulomatosis as compared to rheumatoid arthritis and chronic rhinosinusitis with nasal polyps, Clin. Exp. Rheumatol. 28 (2010) 51–55.
- A. Niederfuhr, H. Kirsche, T. Deutschle, S. Poppert, et al, Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis. Allergy 63 (2008) 1359–1367.
- M. Burian, C. Wolz, C. Goerke, Regulatory adaptation of Staphylococcus aureus during nasal colonization of humans, PLoS One (2010).
Toplam 30 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Mühendislik |
| Bölüm | Research Article |
| Yazarlar | |
| Proje Numarası | 095 nolu BAP projesi |
| Yayımlanma Tarihi | 7 Kasım 2023 |
| Kabul Tarihi | 20 Eylül 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 51 Sayı: 4 |
Kaynak Göster
HACETTEPE JOURNAL OF BIOLOGY AND CHEMİSTRY
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