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Year 2023, Volume: 7 Issue: 2, 229 - 238, 31.12.2023

İbrahim Demirtas Tevfik Ozen Sarmad Marah Doğukan Mutlu Şevki Arslan Fatih Gül

https://doi.org/10.32571/ijct.1360577

Abstract

References

  • Boudet, A.-M., Phytochemistry. 2007, 68 (22-24), 2722-2735.
  • Cannell, R. J. P. Natural Products Isolation, Humana Press: 1998.
  • Dewick, P. M. Medicinal Natural Products: A Biosynthetic Approach, Wiley: 2002.
  • Bhattacharya, A.; Sood, P.; Citovsky, V., Mol. Plant Pathol. 2010, 11 (5), 705-719.
  • Mathai, K., Nutrition in the adult years. In Krause’s food, nutrition, and diet therapy, 10th ed., ed. LK Mahan and S. Escott-Stump, 2000; Vol. 271, pp 274-275.
  • Gibson, E. L.; Wardle, J.; Watts, C. J., Appetite. 1998, 31 (2), 205-228.
  • Grzesik, M.; Naparło, K.; Bartosz, G.; Sadowska-Bartosz, I., Food Chem. 2018, 241, 480-492.
  • Phaniendra, A.; Jestadi, D. B.; Periyasamy, L., Indian J. Clin. Biochem. 2015, 30 (1), 11-26.
  • Gomaa, E. Z., J. Genet. Eng. Biotechnol. 2017, 15 (1), 49-57.
  • Roleira, F. M.; Tavares-da-Silva, E. J.; Varela, C. L.; Costa, S. C.; Silva, T.; Garrido, J.; Borges, F., Food Chem. 2015, 183, 235-258.
  • Karabulut, H.; Gülay, M. Ş., MAE. Vet. Fak. Derg. 2016, 1 (1), 65-76.
  • Liu, R. H., Adv. Nutr. 2013, 4 (3), 384S-392S.
  • Wen, L.; Guo, X.; Liu, R. H.; You, L.; Abbasi, A. M.; Fu, X., Food Chem. 2015, 186, 54-62.
  • Saxena, M.; Saxena, J.; Pradhan, A., Int. J. Pharm. Sci. Rev. Res. 2012, 16 (2), 130-134.
  • Rauf, A.; Jehan, N., Natural products as a potential enzyme inhibitors from medicinal plants. In Enzyme Inhibitors and Activators, InTech, Rijeka: 2017; pp 165-177.
  • Shapiro, R.; Vallee, B. L., Biochemistry. 1991, 30 (8), 2246-2255.
  • Coșarcă, S.-L.; Moacă, E.-A.; Tanase, C.; Muntean, D. L.; Pavel, I. Z.; Dehelean, C. A., Wood Sci. Technol. 2019, 53 (2), 313-333.
  • Tanase, C.; Coșarcă, S.; Muntean, D.-L., Molecules. 2019, 24 (6), 1182.
  • Cao, J.; Han, J.; Xiao, H.; Qiao, J.; Han, M., Nutrients. 2016, 8 (12), 762.
  • Farjon, A. World checklist and bibliography of conifers, Royal Botanic Gardens: 2001.
  • Gernandt, D. S.; López, G. G.; García, S. O.; Liston, A., Taxon. 2005, 54 (1), 29-42.
  • Politeo, O.; Skocibusic, M.; Maravic, A.; Ruscic, M.; Milos, M., Chem. Biodivers. 2011, 8 (3), 540-547.
  • Baytop, T., Pub. istanbul Univ. 1999, 312.
  • Özkut, M.; Albayrak, G.; Sönmez, P. K.; Şen, B.; Toros, P.; Öztürk, Ş.; Çöllü, F.; İnan, S.; Tuğlu, M. İ., MDPI. 2017, 1 (10), 1020.
  • Bogunic, F.; Muratovic, E.; Ballian, D.; Siljak-Yakovlev, S.; Brown, S., Environmental and Experimental Botany. 2007, 59 (3), 354-360.
  • Šarac, Z.; Matejić, J. S.; Stojanović-Radić, Z. Z.; Veselinović, J. B.; Džamić, A. M.; Bojović, S.; Marin, P. D., Computers in biology and medicine. 2014, 54, 72-78.
  • Romani, A.; Ieri, F.; Turchetti, B.; Mulinacci, N.; Vincieri, F.; Buzzini, P., Journal of Pharmaceutical and Biomedical Analysis. 2006, 41 (2), 415-420.
  • Marah, S.; Demirtas, İ.; Tevfik, O., Int. J. Chem. Technol. 2022, 6 (2), 164-169.
  • Golmakani, E.; Mohammadi, A.; Sani, T. A.; Kamali, H., J. Supercrit Fluid. 2014, 95, 318-324.
  • Chang, C.-C.; Yang, M.-H.; Wen, H.-M.; Chern, J.-C., J. Food Drug Anal. 2002, 10 (3).
  • Yilmaz, M. A., Industrial Crops and Products. 2020, 149, 112347.
  • Ma, D.; Chen, C.-B.; Jhanji, V.; Xu, C.; Yuan, X.-L.; Liang, J.-J.; Huang, Y.; Cen, L.-P.; Ng, T. K., Eye. 2020, 34 (7), 1212-1219.
  • Kuscu, C.; Mammadov, R.; Czikora, A.; Unlu, H.; Tufan, T.; Fischer, N. L.; Arslan, S.; Bekiranov, S.; Kanemaki, M.; Adli, M., J. Mol. Biol. 2019, 431 (1), 111-121.
  • Ercan, P.; El, S. N., Food Chem. 2016, 205, 163-169.
  • Yenigün, S.; Başar, Y.; İpek, Y.; Behçet, L.; Özen, T.; Demirtaş, İ., Journal of Biomolecular Structure and Dynamics. 2023, 1-18.
  • Mayur, B.; Sancheti, S.; Shruti, S.; Sung-Yum, S., J. Med. Plant Res. 2010, 4 (15), 1547-1553.
  • Sancheti, S.; Sancheti, S.; Seo, S.-Y., Pak. J. Pharm. Sci. 2010, 23 (2).
  • Andrews, J. M., J. Antimicrob. Chemother. 2001, 48 (suppl_1), 5-16.
  • Yakan, H.; Omer, H.-H.; Buruk, O.; Çakmak, Ş.; Marah, S.; Veyisoğlu, A.; Muğlu, H.; Ozen, T.; Kütük, H., Journal of Molecular Structure. 2023, 1277, 134799.
  • Baiseitova, A.; Jenis, J.; Kim, J. Y.; Li, Z. P.; Park, K. H., Nat. Prod. Res. 2021, 35 (5), 880-883.
  • Russo, A.; Izzo, A. A.; Borrelli, F.; Renis, M.; Vanella, A., Phytother. Res. 2003, 17 (8), 870-875.
  • Tepe, B.; Degerli, S.; Arslan, S.; Malatyali, E.; Sarikurkcu, C., Fitoterapia. 2011, 82 (2), 237-246.
  • Sevgi, K.; Tepe, B.; Sarikurkcu, C., Food and Chemical Toxicology. 2015, 77, 12-21.
  • Bianchi, S.; Zikeli, F.; Vinciguerra, V.; Kroslakova, I.; Mayer, I.; Pichelin, F.; Matteucci, G., Holzforschung. 2019, 73 (4), 353-361.
  • Nisca, A.; Ștefănescu, R.; Stegăruș, D. I.; Mare, A. D.; Farczadi, L.; Tanase, C., Antioxidants. 2021, 10 (2), 327.
  • Milić, N.; Milanović, M.; Četojević‐Simin, D.; Malenčić, Đ.; Prvulović, D.; Pavkov, N.; Radulović, Z.; Milošević, N.; Rašković, A.; Mandić, A., Arch. Pharm. 2021, e2000416.
  • Skrypnik, L.; Grigorev, N.; Michailov, D.; Antipina, M.; Danilova, M.; Pungin, A., Eur. J. Wood Wood Prod. 2019, 77 (5), 879-890.
  • Kilic, I., Curr. Pharm. Anal. 2016, 12 (2), 146-151.
  • Ustun, O.; Senol, F. S.; Kurkcuoglu, M.; Orhan, I. E.; Kartal, M.; Baser, K. H. C., Industrial crops and products. 2012, 38, 115-123.
  • Ferreira-Santos, P.; Genisheva, Z.; Botelho, C.; Santos, J.; Ramos, C.; Teixeira, J. A.; Rocha, C. M., Antioxidants. 2020, 9 (4), 334.
  • Topal, M., Rec. Nat. Prod. 2020, 14, 129-138.
  • Zulfqar, F.; Akhtar, M. F.; Saleem, A.; Akhtar, B.; Sharif, A.; Saleem, U., J. Food Biochem. 2020, 44 (6), e13199.
  • Silva, K. R. d.; Damasceno, J. L.; Inácio, M. d. O.; Abrão, F.; Ferreira, N. H.; Tavares, D. C.; Ambrosio, S. R.; Veneziani, R. C. S.; Martins, C. H. G., Front. Microbiol. 2019, 10, 987.
  • Merah, S.; Dahmane, D.; Krimat, S.; Metidji, H.; Nouasri, A.; Lamari, L.; Dob, T., Bangladesh J. Pharmacol. 2018, 13 (2), 120-29.
  • Ashok, B. T.; Ali, R., Exp. Gerontol. 1999, 34 (3), 293-303.
  • Ochi, T.; Cerutti, P. A., Proc. Natl. Acad. Sci. 1987, 84 (4), 990-994.

Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements

Year 2023, Volume: 7 Issue: 2, 229 - 238, 31.12.2023

İbrahim Demirtas Tevfik Ozen Sarmad Marah Doğukan Mutlu Şevki Arslan Fatih Gül

https://doi.org/10.32571/ijct.1360577

Abstract

Özet
Bu günlerde, zarar verme potansiyelinin düşük olması ve düşük maliyetle geliştirilebilmesi nedeniyle yeni bitki tıbbi kaynaklarına olan ihtiyaç arttmaktadır. Çam bitkisinin mükemmel doğal ve ekonomik katkıları vardır. Ayrıca çam ekstraktları çok sayıda biyoaktif kimyasal bileşiklere sahiptir. Bu çalışmada Pinus sylvestris kabuğu (PSB: Sarı Çam) ve Pinus nigra kabuğu (PNB: Kara Çam) ekstraktlarının kimyasal bileşimini ve biyoaktivitesini belirlemeyi ve ayrıca ticari bir ürünü karşılaştırmayı amaçladık. PSB ekstraktı kolon kromatografisi ile fraksiyonlara ayrıldı. PSB ekstraktının PSB-FR-2 fraksiyonu, 157.62±1.06 mg GAE g-1 ekstraktı gibi yüksek bir fenolik içeriğe sahipti. PNB ve PSB ekstraktlarının -amilaz ve -glukosidaza karşı inhibitör aktiviteleri, akarbozla karşılaştırıldığında akarbozun iki katı aktivite göstermiştir. Üstelik qPCR testi, PSB ekstraktının, 50 µg mL-1 gibi en düşük konsantrasyonda bile akciğer hücrelerinde ACE2 geninin ekspresyonunu azaltabildiğini gösterdi. MIC testi, ekstraktların potansiyel olarak antibakteriyel etkilere sahip olabileceğini gösterdi.
Sonuçlarımız, PNB, PSB ekstraktları ve PBS fraksiyonlarının yüksek fenolik ve flavonoid metabolit içeriğinin yanı sıra çeşitli biyoaktiviteye sahip olduğunu ortaya koymaktadır. Dolayısıyla, ileriye yönelik çalışmalar için umut verici bir doğal tıbbi ürün modeli olabilir.

Keywords

Pinus nigra Pinus sylvestris phytochemical component cytotoxic activity antibacterial activity enzyme inhibition DNA protective activity

Thanks

All authors are grateful to the ERSAG for presenting the PNB and PSB extracts and fractions. Iğdır University Research Laboratory Application and Research Center (ALUM) performed the approach's evaluation and the LC-ESI-MS/MS measurement for this research. As a project researchers, we would also like to express our gratitude to the institutions concerned.

References

  • Boudet, A.-M., Phytochemistry. 2007, 68 (22-24), 2722-2735.
  • Cannell, R. J. P. Natural Products Isolation, Humana Press: 1998.
  • Dewick, P. M. Medicinal Natural Products: A Biosynthetic Approach, Wiley: 2002.
  • Bhattacharya, A.; Sood, P.; Citovsky, V., Mol. Plant Pathol. 2010, 11 (5), 705-719.
  • Mathai, K., Nutrition in the adult years. In Krause’s food, nutrition, and diet therapy, 10th ed., ed. LK Mahan and S. Escott-Stump, 2000; Vol. 271, pp 274-275.
  • Gibson, E. L.; Wardle, J.; Watts, C. J., Appetite. 1998, 31 (2), 205-228.
  • Grzesik, M.; Naparło, K.; Bartosz, G.; Sadowska-Bartosz, I., Food Chem. 2018, 241, 480-492.
  • Phaniendra, A.; Jestadi, D. B.; Periyasamy, L., Indian J. Clin. Biochem. 2015, 30 (1), 11-26.
  • Gomaa, E. Z., J. Genet. Eng. Biotechnol. 2017, 15 (1), 49-57.
  • Roleira, F. M.; Tavares-da-Silva, E. J.; Varela, C. L.; Costa, S. C.; Silva, T.; Garrido, J.; Borges, F., Food Chem. 2015, 183, 235-258.
  • Karabulut, H.; Gülay, M. Ş., MAE. Vet. Fak. Derg. 2016, 1 (1), 65-76.
  • Liu, R. H., Adv. Nutr. 2013, 4 (3), 384S-392S.
  • Wen, L.; Guo, X.; Liu, R. H.; You, L.; Abbasi, A. M.; Fu, X., Food Chem. 2015, 186, 54-62.
  • Saxena, M.; Saxena, J.; Pradhan, A., Int. J. Pharm. Sci. Rev. Res. 2012, 16 (2), 130-134.
  • Rauf, A.; Jehan, N., Natural products as a potential enzyme inhibitors from medicinal plants. In Enzyme Inhibitors and Activators, InTech, Rijeka: 2017; pp 165-177.
  • Shapiro, R.; Vallee, B. L., Biochemistry. 1991, 30 (8), 2246-2255.
  • Coșarcă, S.-L.; Moacă, E.-A.; Tanase, C.; Muntean, D. L.; Pavel, I. Z.; Dehelean, C. A., Wood Sci. Technol. 2019, 53 (2), 313-333.
  • Tanase, C.; Coșarcă, S.; Muntean, D.-L., Molecules. 2019, 24 (6), 1182.
  • Cao, J.; Han, J.; Xiao, H.; Qiao, J.; Han, M., Nutrients. 2016, 8 (12), 762.
  • Farjon, A. World checklist and bibliography of conifers, Royal Botanic Gardens: 2001.
  • Gernandt, D. S.; López, G. G.; García, S. O.; Liston, A., Taxon. 2005, 54 (1), 29-42.
  • Politeo, O.; Skocibusic, M.; Maravic, A.; Ruscic, M.; Milos, M., Chem. Biodivers. 2011, 8 (3), 540-547.
  • Baytop, T., Pub. istanbul Univ. 1999, 312.
  • Özkut, M.; Albayrak, G.; Sönmez, P. K.; Şen, B.; Toros, P.; Öztürk, Ş.; Çöllü, F.; İnan, S.; Tuğlu, M. İ., MDPI. 2017, 1 (10), 1020.
  • Bogunic, F.; Muratovic, E.; Ballian, D.; Siljak-Yakovlev, S.; Brown, S., Environmental and Experimental Botany. 2007, 59 (3), 354-360.
  • Šarac, Z.; Matejić, J. S.; Stojanović-Radić, Z. Z.; Veselinović, J. B.; Džamić, A. M.; Bojović, S.; Marin, P. D., Computers in biology and medicine. 2014, 54, 72-78.
  • Romani, A.; Ieri, F.; Turchetti, B.; Mulinacci, N.; Vincieri, F.; Buzzini, P., Journal of Pharmaceutical and Biomedical Analysis. 2006, 41 (2), 415-420.
  • Marah, S.; Demirtas, İ.; Tevfik, O., Int. J. Chem. Technol. 2022, 6 (2), 164-169.
  • Golmakani, E.; Mohammadi, A.; Sani, T. A.; Kamali, H., J. Supercrit Fluid. 2014, 95, 318-324.
  • Chang, C.-C.; Yang, M.-H.; Wen, H.-M.; Chern, J.-C., J. Food Drug Anal. 2002, 10 (3).
  • Yilmaz, M. A., Industrial Crops and Products. 2020, 149, 112347.
  • Ma, D.; Chen, C.-B.; Jhanji, V.; Xu, C.; Yuan, X.-L.; Liang, J.-J.; Huang, Y.; Cen, L.-P.; Ng, T. K., Eye. 2020, 34 (7), 1212-1219.
  • Kuscu, C.; Mammadov, R.; Czikora, A.; Unlu, H.; Tufan, T.; Fischer, N. L.; Arslan, S.; Bekiranov, S.; Kanemaki, M.; Adli, M., J. Mol. Biol. 2019, 431 (1), 111-121.
  • Ercan, P.; El, S. N., Food Chem. 2016, 205, 163-169.
  • Yenigün, S.; Başar, Y.; İpek, Y.; Behçet, L.; Özen, T.; Demirtaş, İ., Journal of Biomolecular Structure and Dynamics. 2023, 1-18.
  • Mayur, B.; Sancheti, S.; Shruti, S.; Sung-Yum, S., J. Med. Plant Res. 2010, 4 (15), 1547-1553.
  • Sancheti, S.; Sancheti, S.; Seo, S.-Y., Pak. J. Pharm. Sci. 2010, 23 (2).
  • Andrews, J. M., J. Antimicrob. Chemother. 2001, 48 (suppl_1), 5-16.
  • Yakan, H.; Omer, H.-H.; Buruk, O.; Çakmak, Ş.; Marah, S.; Veyisoğlu, A.; Muğlu, H.; Ozen, T.; Kütük, H., Journal of Molecular Structure. 2023, 1277, 134799.
  • Baiseitova, A.; Jenis, J.; Kim, J. Y.; Li, Z. P.; Park, K. H., Nat. Prod. Res. 2021, 35 (5), 880-883.
  • Russo, A.; Izzo, A. A.; Borrelli, F.; Renis, M.; Vanella, A., Phytother. Res. 2003, 17 (8), 870-875.
  • Tepe, B.; Degerli, S.; Arslan, S.; Malatyali, E.; Sarikurkcu, C., Fitoterapia. 2011, 82 (2), 237-246.
  • Sevgi, K.; Tepe, B.; Sarikurkcu, C., Food and Chemical Toxicology. 2015, 77, 12-21.
  • Bianchi, S.; Zikeli, F.; Vinciguerra, V.; Kroslakova, I.; Mayer, I.; Pichelin, F.; Matteucci, G., Holzforschung. 2019, 73 (4), 353-361.
  • Nisca, A.; Ștefănescu, R.; Stegăruș, D. I.; Mare, A. D.; Farczadi, L.; Tanase, C., Antioxidants. 2021, 10 (2), 327.
  • Milić, N.; Milanović, M.; Četojević‐Simin, D.; Malenčić, Đ.; Prvulović, D.; Pavkov, N.; Radulović, Z.; Milošević, N.; Rašković, A.; Mandić, A., Arch. Pharm. 2021, e2000416.
  • Skrypnik, L.; Grigorev, N.; Michailov, D.; Antipina, M.; Danilova, M.; Pungin, A., Eur. J. Wood Wood Prod. 2019, 77 (5), 879-890.
  • Kilic, I., Curr. Pharm. Anal. 2016, 12 (2), 146-151.
  • Ustun, O.; Senol, F. S.; Kurkcuoglu, M.; Orhan, I. E.; Kartal, M.; Baser, K. H. C., Industrial crops and products. 2012, 38, 115-123.
  • Ferreira-Santos, P.; Genisheva, Z.; Botelho, C.; Santos, J.; Ramos, C.; Teixeira, J. A.; Rocha, C. M., Antioxidants. 2020, 9 (4), 334.
  • Topal, M., Rec. Nat. Prod. 2020, 14, 129-138.
  • Zulfqar, F.; Akhtar, M. F.; Saleem, A.; Akhtar, B.; Sharif, A.; Saleem, U., J. Food Biochem. 2020, 44 (6), e13199.
  • Silva, K. R. d.; Damasceno, J. L.; Inácio, M. d. O.; Abrão, F.; Ferreira, N. H.; Tavares, D. C.; Ambrosio, S. R.; Veneziani, R. C. S.; Martins, C. H. G., Front. Microbiol. 2019, 10, 987.
  • Merah, S.; Dahmane, D.; Krimat, S.; Metidji, H.; Nouasri, A.; Lamari, L.; Dob, T., Bangladesh J. Pharmacol. 2018, 13 (2), 120-29.
  • Ashok, B. T.; Ali, R., Exp. Gerontol. 1999, 34 (3), 293-303.
  • Ochi, T.; Cerutti, P. A., Proc. Natl. Acad. Sci. 1987, 84 (4), 990-994.
There are 56 citations in total.

Details

Primary Language English
Subjects Structural Biology, Food Engineering
Journal Section Research Articles
Authors

İbrahim Demirtas 0000-0001-8946-647X

Tevfik Ozen 0000-0003-0133-5630

Sarmad Marah 0000-0001-6765-4605

Doğukan Mutlu 0000-0003-3259-5822

Şevki Arslan 0000-0002-4215-5006

Fatih Gül 0000-0002-4297-786X

Early Pub Date January 10, 2024
Publication Date December 31, 2023
Published in Issue Year 2023 Volume: 7 Issue: 2

Cite

APA Demirtas, İ., Ozen, T., Marah, S., Mutlu, D., et al. (2023). Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements. International Journal of Chemistry and Technology, 7(2), 229-238. https://doi.org/10.32571/ijct.1360577
AMA Demirtas İ, Ozen T, Marah S, Mutlu D, Arslan Ş, Gül F. Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements. Int. J. Chem. Technol. December 2023;7(2):229-238. doi:10.32571/ijct.1360577
Chicago Demirtas, İbrahim, Tevfik Ozen, Sarmad Marah, Doğukan Mutlu, Şevki Arslan, and Fatih Gül. “Functional Food Components and Activities of Pinus Nigra and Pinus Sylvestris Barks As Food Supplements”. International Journal of Chemistry and Technology 7, no. 2 (December 2023): 229-38. https://doi.org/10.32571/ijct.1360577.
EndNote Demirtas İ, Ozen T, Marah S, Mutlu D, Arslan Ş, Gül F (December 1, 2023) Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements. International Journal of Chemistry and Technology 7 2 229–238.
IEEE İ. Demirtas, T. Ozen, S. Marah, D. Mutlu, Ş. Arslan, and F. Gül, “Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements”, Int. J. Chem. Technol., vol. 7, no. 2, pp. 229–238, 2023, doi: 10.32571/ijct.1360577.
ISNAD Demirtas, İbrahim et al. “Functional Food Components and Activities of Pinus Nigra and Pinus Sylvestris Barks As Food Supplements”. International Journal of Chemistry and Technology 7/2 (December 2023), 229-238. https://doi.org/10.32571/ijct.1360577.
JAMA Demirtas İ, Ozen T, Marah S, Mutlu D, Arslan Ş, Gül F. Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements. Int. J. Chem. Technol. 2023;7:229–238.
MLA Demirtas, İbrahim et al. “Functional Food Components and Activities of Pinus Nigra and Pinus Sylvestris Barks As Food Supplements”. International Journal of Chemistry and Technology, vol. 7, no. 2, 2023, pp. 229-38, doi:10.32571/ijct.1360577.
Vancouver Demirtas İ, Ozen T, Marah S, Mutlu D, Arslan Ş, Gül F. Functional food components and activities of Pinus nigra and Pinus sylvestris barks as food supplements. Int. J. Chem. Technol. 2023;7(2):229-38.

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