Research Article
ENDOMETRİOMA NEDENİYLE LAPAROSKOPİK CERRAHİ GEÇİREN HASTA GRUBUNDA AGONİST VE ANTAGONİST TEDAVİ PROTOLLERİNİN IVF PROGNOZUNA ETKİSİ*
Abstract
Endometriosiz kronik, yaygın, östrojen bağımlı inflamatuvar bir hastalıktır. Bu hastalığın kesin prevalansı bilinmemekle birlikte üreme dönemindeki kadınları %2-10 oranında etkilediği tahmin edilmektedir. Bu çalışmada endometrioma nedeniyle laparoskobik cerrahi geçiren hastalarda uygulanan agonist ve antagonist protokollerin İVF prognozuna etkisinin belirlenmesi amaçlanmıştır. Buna göre Ankara Etlik Zübeyde Hanım kadın hastalıkları ve eğitim araştırma hastanesinde 2007-2015 yılları arasında endometrioma nedeniyle IVF kliniğinde tedavi programına alınan hastaların dosyaları taranmıştır. Endometrioma tanısı alan ve bu sebeple opere olmuş 64 siklus çalışmaya dahil edilmiştir.
Çalışmada agonist ve antagonist tedavi grubu olarak ikiye ayrılan toplam 64 hastanın bazal 3. gün FSH düzeyi antagonist grupta agonist tedavi grubuna göre çok önemli derecede anlamlı bulunmuştur. Stimülasyon parametrelerinden GnRH kullanım süresi agonist tedavi grubunda antagonist tedavi grubuna kıyasla istatistiksel olarak çok önemli seviyede uzun bulunmuştur. Diğer taraftan, fertilizasyon oranı agonist grupta antagoniste göre istatistiksel olarak yüksek bulunmuştur.
References
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- 8. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertility and sterility. 2002;77(6):1148-55.
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- 14. Suzuki T, Izumi S, Matsubayashi H, Awaji H, Yoshikata K, Makino T. Impact of ovarian endometrioma on oocytes and pregnancy outcome in in vitro fertilization. Fertility and sterility. 2005;83(4):908-13.
- 15. Bastu E, Yasa C, Dural O, Mutlu MF, Celik C, Ugurlucan FG, et al. Comparison of ovulation induction protocols after endometrioma resection. JSLS : Journal of the Society of Laparoendoscopic Surgeons. 2014;18(3).
- 16. Pabuccu R, Onalan G, Kaya C. GnRH agonist and antagonist protocols for stage I-II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertility and sterility. 2007;88(4):832-9.
Year 2023,
Volume: 9 Issue: 2, 63 - 75, 31.08.2023
Abstract
References
- 1. Tomassetti C, Johnson NP, Petrozza J, Abrao MS, Einarsson JI, Horne AW, et al. An International Terminology for Endometriosis, 2021. Facts, views & vision in ObGyn. 2021;13(4):295-304.
- 2. Saunders PTK, Horne AW. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell. 2021;184(11):2807-24.
- 3. Prescott J, Farland LV, Tobias DK, Gaskins AJ, Spiegelman D, Chavarro JE, et al. A prospective cohort study of endometriosis and subsequent risk of infertility. Human reproduction (Oxford, England). 2016;31(7):1475-82.
- 4. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-49.
- 5. Farquhar C. Endometriosis. BMJ (Clinical research ed). 2007;334(7587):249-53.
- 6. Holoch KJ, Lessey BA. Endometriosis and infertility. Clinical obstetrics and gynecology. 2010;53(2):429-38.
- 7. Gupta S, Agarwal A, Agarwal R, Loret de Mola JR. Impact of ovarian endometrioma on assisted reproduction outcomes. Reproductive biomedicine online. 2006;13(3):349-60.
- 8. Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertility and sterility. 2002;77(6):1148-55.
- 9. Omland AK, Abyholm T, Fedorcsák P, Ertzeid G, Oldereid NB, Bjercke S, et al. Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility. Human reproduction (Oxford, England). 2005;20(3):722-7.
- 10. Surrey ES. Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies. BioMed research international. 2015;2015:482959.
- 11. Shrestha D, La X, Feng HL. Comparison of different stimulation protocols used in in vitro fertilization: a review. Annals of translational medicine. 2015;3(10):137.
- 12. Singh AK, Chakravarty B, Chaudhury K. Nanoparticle-Assisted Combinatorial Therapy for Effective Treatment of Endometriosis. Journal of biomedical nanotechnology. 2015;11(5):789-804.
- 13. Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertility and sterility. 2007;88(6):1568-72.
- 14. Suzuki T, Izumi S, Matsubayashi H, Awaji H, Yoshikata K, Makino T. Impact of ovarian endometrioma on oocytes and pregnancy outcome in in vitro fertilization. Fertility and sterility. 2005;83(4):908-13.
- 15. Bastu E, Yasa C, Dural O, Mutlu MF, Celik C, Ugurlucan FG, et al. Comparison of ovulation induction protocols after endometrioma resection. JSLS : Journal of the Society of Laparoendoscopic Surgeons. 2014;18(3).
- 16. Pabuccu R, Onalan G, Kaya C. GnRH agonist and antagonist protocols for stage I-II endometriosis and endometrioma in in vitro fertilization/intracytoplasmic sperm injection cycles. Fertility and sterility. 2007;88(4):832-9.
There are 16 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Gynecologic Oncology Surgery |
| Journal Section | Research Article |
| Authors | |
| Publication Date | August 31, 2023 |
| Published in Issue | Year 2023 Volume: 9 Issue: 2 |
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