Research Article
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Multipl skleroz hastalarında nöropsikiyatrik bulguların incelenmesi

Year 2022, Volume: 47 Issue: 1, 208 - 218, 31.03.2022
https://doi.org/10.17826/cumj.1018632

Abstract

Amaç: Bu çalışmanın amacı; multipl skleroz (MS) hastalarında apati ve emosyonel labilite gibi nöropsikiyatrik semptomları ve bunların eşlik eden diğer faktörlerle ilişkisini kapsamlı bir şekilde değerlendirmektir.
Gereç ve Yöntem: 258 MS hastasına Montreal bilişsel değerlendirme (MoCA), Apati değerlendirme ölçeği (AES), Yorgunluk şiddeti ölçeği (FSS), Emosyonel Labilite (CNS-LS), Beck Depresyon Envanteri (BDI) uygulandı. Ölçekler ve diğer olası nedenler arasında korelasyon ve regresyon analizleri yapıldı.
Bulgular: Hastaların %53,6'sında emosyonel labilite, %76.2'sinde yorgunluk mevcuttu. Emosyonel labilite ile yorgunluk ve depresyon arasında pozitif korelasyon izlenirken, apati ile emosyonel labilite ve yorgunluk arasında negatif korelasyon saptandı. Ek olarak, apati ve depresyon arasında negatif korelasyon izlendi. Bilişsel bozukluk ile depresyon ve/veya hastalık süresi ve/veya diğer ölçek puanları arasında ilişki yoktu.
Sonuç: Emosyonel labilite ve apati, MS hastalarında oldukça sık görülen ve birbiriyle kesişen/karışan sorunlardır. Buna ek olarak; apati, MS hastalarında ortaya çıkan bağımsız bir nöropsikiyatrik semptom olabilir.

References

  • Demir S, Tutuncu M, Uzunkopru C, Gumus H, Sen S, Gunduz T et al. A comprehensive assessment of patient experience and disease-related awareness in Multiple Sclerosis: A questionnaire-based nation-wide survey in Turkey. Mult Scler Relat Disord. 2021;52:103005.
  • Pandya R, Metz L, Patten SB. Predictive value of the CES-D in detecting depression among candidates for disease-modifying multiple sclerosis treatment. Psychosomatics. 2005;46:131-4.
  • Moore P, Harding KE, Clarkson H, Pickersgill TP, Wardle M, Robertson NP. Demographic and clinical factors associated with changes in employment in multiple sclerosis. Mult Scler. 2013;19:1647-54.
  • Fiest KM, Walker JR, Bernstein CN, Graff LA, Zarychanski R, Abou-Setta AM et al. Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis. Mult Scler Relat Disord. 2016;5:12-26.
  • Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C. The link between multiple sclerosis and depression. Nat Rev Neurol. 2014;10:507-17.
  • Bonelli RM, Cummings JL. Frontal-subcortical circuitry and behavior. Dialogues Clin Neurosci. 2007;9:141-51.
  • Fitzgerald KC, Salter A, Tyry T, Fox RJ, Cutter G, Marrie RA. Pseudobulbar affect: prevalence and association with symptoms in multiple sclerosis. Neurol Clin Pract. 2018;8:472-481.
  • Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G et all. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162-173.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS). Neurology. 1983;33:1444–52.
  • Sullivan MJ, Weinshenker B, Mikail S, Bishop SR. Screening for major depression in the early stages of multiple sclerosis Can J Neurol Sci. 1995;22:228-31.
  • Quaranta D, Marra C, Zinno M. Presentation and validation of the Multiple Sclerosis Depression Rating Scale: a test specifically devised to investigate affective disorders in multiple sclerosis patients. Clin Neuropsychol. 2012;26:571–587.
  • Hisli N. Beck Depresyon Envanteri’nin geçerliği üzerine bir çalışma. Psikoloji Dergisi. 1988;6:118-26.
  • Beck AT, Steer RA, Brown GK. Manual for the Beck depression inventory-II. San Antonio, TX: Psychological Corporation. 1996.
  • Krupp, LB, LaRocca NG, Muir-Nash J, Steinberg AD. The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121-3.
  • Armutlu K, Korkmaz NC, Keser I, Sumbuloglu V, Akbiyik DI, Guney Z et al. The validity and reliability of the fatigue severity scale in Turkish multiple sclerosis patients. Int J Rehabil Res. 2007;30:81-5.
  • Marin RS, Biedrzycki RC, Firinciogullari S. Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res. 1991;38:143-62.
  • Gülseren S, Atun C, Erol A, Aydemir O, Çelebisoy M, Kültür S. The reliability and validity of the turkish version of apathy evaluation scale. Archives of Neuropsychiatry. 2001;38:142-50.
  • Vidović V, Rovazdi MČ, Kraml O, Kes VB. Pseudobulbar affect in multiple sclerosis patients. Acta Clin Croat. 2015;54:159-63.
  • Demir S, Koskderelioglu A, Karaoglan M, Gedizlioglu M, Togrol RE. Pseudobulbar affect prevalence in Turkish multiple sclerosis patients. Medical Science and Discovery. 2018;7:279-283.
  • Mehmet Hamamci. Evaluation of cognitive impairment in relapsing-remitting multiple sclerosis patients by using the Montreal cognitive assessment test. Ann Med Res. 2019;26:2295-8.
  • Aksoy S, Timer E, Mumcu S, Akgün M, Kırak E, Örken DN. Screening for cognitive ımpairment in multiple sclerosis with MOCA Test. Turk J Neurol. 2013;19:52-55.
  • Selekler K, Cangoz B, Uluç S. Power of discrimination of montreal cognıtıve assessment (MOCA) scale in Turkısh patients wıth mild cognıtıve impairement and alzheımer’s dısease. Turkish Journal of Geriatrics. 2010;13:166-71.
  • Hanna J, Feinstein A, Morrow SA. The association of pathological laughing and crying and cognitive impairment in multiple sclerosis. J Neurol Sci. 2016;361:200-3.
  • Andreasen AK, Iversen P, Marstrand L, Siersma V, Siebner HR, Sellebjerg F. Structural and cognitive correlates of fatigue in progressive multiple sclerosis. Neurol Res. 2019;41:168-176.
  • Johansson S, Ytterberg C, Hillert J, Widén Holmqvist L, Von Koch L. A longitudinal study of variations in and predictors of fatigue in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79:454-7.
  • Wood B, Van Der Mei IA, Ponsonby AL, Pittas F, Quinn S, Dwyer T et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Mult Scler. 2013;19:217-24.
  • Mills RJ, Young CA. The relationship between fatigue and other clinical features of multiple sclerosis. Mult Scler. 2011;17:604-12.
  • Langeskov-Christensen M, Bisson EJ, Finlayson ML, Dalgas U. Potential pathophysiological pathways that can explain the positive effects of exercise on fatigue in multiple sclerosis: a scoping review. J Neurol Sci. 2017;373:307-20.
  • Rooney S, Wood L, Moffat F, Paul L. Prevalence of fatigue and its association with clinical features in progressive and non-progressive forms of multiple sclerosis. Mult Scler Relat Disord. 2019;28:276-82.
  • Niino M, Mifune N, Kohriyama T, Mori M, Ohashi T, Kawachi I et al. Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis. BMC Neurol. 2014;14:3.
  • Biberacher V, Schmidt P, Selter RC, Pernpeinter V, Kowarik MC, Knier B et al. Fatigue in multiple sclerosis: associations with clinical, mri and csf parameters. Mult Scler. 2018;24:1115-25.
  • Iriarte J, Subirá ML, Castro P. Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors. Mult Scler. 2000;6:124-30.
  • Herring TE, Alschuler KN, Knowles LM, Phillips KM, Morean WM, Turner AP et al. Differences in correlates of fatigue between relapsing and progressive forms of multiple sclerosis. Mult Scler Relat Disord. 2021;54:103109.
  • Rosti-Otajärvi E, Hämäläinen P. Behavioural symptoms and impairments in multiple sclerosis: a systematic review and meta-analysis. Mult Scler. 2013;19:31-45.
  • De Paepe AE, Sierpowska J, Garcia-Gorro C, Martinez-Horta S, Perez-Perez J, Kulisevsky J et al. White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease. Neuroimage Clin. 2019;24:101965.
  • Figved N, Benedict R, Klevan G, Myhr KM, Nyland HI, Landrø NI et al. Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis. Mult Scler. 2008;14:1084-90.
  • Lester K, Stepleman L, Hughes M. The association of illness severity, self-reported cognitive impairment, and perceived illness management with depression and anxiety in a multiple sclerosis clinic population. J Behav Med. 2007;30:177-86.
  • Patti F, Amato MP, Trojano M, Bastianello S, Tola MR, Goretti B et al. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the cognitive impairment in multiple sclerosis (COGIMUS) study. Mult Scler. 2009;15:779-88.

Evaluation of neuropsychiatric symptoms in patients with multiple sclerosis

Year 2022, Volume: 47 Issue: 1, 208 - 218, 31.03.2022
https://doi.org/10.17826/cumj.1018632

Abstract

Purpose: The aim of this study was to comprehensively assess the neurophyschiatric symptoms of multiple sclerosis (MS) such as apathy and pseudobulbar affect and their correlation with other concomitant factors.
Materials and Methods: Montreal Cognitive Assessment (MoCA), Apathy Evaluation Scale (AES), Fatigue severity scale (FSS), Center for Neurologic Study-Lability Scale (CNS-LS), Beck Depression Inventory (BDI) are applied to 258 MS patients. Correlation and regression analysis are conducted between scales and other possible causers.
Results: 53.6% of the patients have psuedobulbar affect, 76.2% of patient population have fatigue. Pseudobulbar affect had positive correlation with fatigue and also depression while apathy negatively correlate with pseudobulbar affect or fatigue. Additionally, apathy and depression correlated negatively. There was no relation between cognition and depression and/or disease duration and/or other scales’ scores.
Conclusion: Pseudobulbar affect and apathy are quite common symptoms in MS patients, that are cross-cutting issues. Also, apathy may be an independent neuropyschiatric symptom of MS that need to be approached separately.

References

  • Demir S, Tutuncu M, Uzunkopru C, Gumus H, Sen S, Gunduz T et al. A comprehensive assessment of patient experience and disease-related awareness in Multiple Sclerosis: A questionnaire-based nation-wide survey in Turkey. Mult Scler Relat Disord. 2021;52:103005.
  • Pandya R, Metz L, Patten SB. Predictive value of the CES-D in detecting depression among candidates for disease-modifying multiple sclerosis treatment. Psychosomatics. 2005;46:131-4.
  • Moore P, Harding KE, Clarkson H, Pickersgill TP, Wardle M, Robertson NP. Demographic and clinical factors associated with changes in employment in multiple sclerosis. Mult Scler. 2013;19:1647-54.
  • Fiest KM, Walker JR, Bernstein CN, Graff LA, Zarychanski R, Abou-Setta AM et al. Systematic review and meta-analysis of interventions for depression and anxiety in persons with multiple sclerosis. Mult Scler Relat Disord. 2016;5:12-26.
  • Feinstein A, Magalhaes S, Richard JF, Audet B, Moore C. The link between multiple sclerosis and depression. Nat Rev Neurol. 2014;10:507-17.
  • Bonelli RM, Cummings JL. Frontal-subcortical circuitry and behavior. Dialogues Clin Neurosci. 2007;9:141-51.
  • Fitzgerald KC, Salter A, Tyry T, Fox RJ, Cutter G, Marrie RA. Pseudobulbar affect: prevalence and association with symptoms in multiple sclerosis. Neurol Clin Pract. 2018;8:472-481.
  • Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G et all. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018;17:162-173.
  • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS). Neurology. 1983;33:1444–52.
  • Sullivan MJ, Weinshenker B, Mikail S, Bishop SR. Screening for major depression in the early stages of multiple sclerosis Can J Neurol Sci. 1995;22:228-31.
  • Quaranta D, Marra C, Zinno M. Presentation and validation of the Multiple Sclerosis Depression Rating Scale: a test specifically devised to investigate affective disorders in multiple sclerosis patients. Clin Neuropsychol. 2012;26:571–587.
  • Hisli N. Beck Depresyon Envanteri’nin geçerliği üzerine bir çalışma. Psikoloji Dergisi. 1988;6:118-26.
  • Beck AT, Steer RA, Brown GK. Manual for the Beck depression inventory-II. San Antonio, TX: Psychological Corporation. 1996.
  • Krupp, LB, LaRocca NG, Muir-Nash J, Steinberg AD. The Fatigue Severity Scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46:1121-3.
  • Armutlu K, Korkmaz NC, Keser I, Sumbuloglu V, Akbiyik DI, Guney Z et al. The validity and reliability of the fatigue severity scale in Turkish multiple sclerosis patients. Int J Rehabil Res. 2007;30:81-5.
  • Marin RS, Biedrzycki RC, Firinciogullari S. Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res. 1991;38:143-62.
  • Gülseren S, Atun C, Erol A, Aydemir O, Çelebisoy M, Kültür S. The reliability and validity of the turkish version of apathy evaluation scale. Archives of Neuropsychiatry. 2001;38:142-50.
  • Vidović V, Rovazdi MČ, Kraml O, Kes VB. Pseudobulbar affect in multiple sclerosis patients. Acta Clin Croat. 2015;54:159-63.
  • Demir S, Koskderelioglu A, Karaoglan M, Gedizlioglu M, Togrol RE. Pseudobulbar affect prevalence in Turkish multiple sclerosis patients. Medical Science and Discovery. 2018;7:279-283.
  • Mehmet Hamamci. Evaluation of cognitive impairment in relapsing-remitting multiple sclerosis patients by using the Montreal cognitive assessment test. Ann Med Res. 2019;26:2295-8.
  • Aksoy S, Timer E, Mumcu S, Akgün M, Kırak E, Örken DN. Screening for cognitive ımpairment in multiple sclerosis with MOCA Test. Turk J Neurol. 2013;19:52-55.
  • Selekler K, Cangoz B, Uluç S. Power of discrimination of montreal cognıtıve assessment (MOCA) scale in Turkısh patients wıth mild cognıtıve impairement and alzheımer’s dısease. Turkish Journal of Geriatrics. 2010;13:166-71.
  • Hanna J, Feinstein A, Morrow SA. The association of pathological laughing and crying and cognitive impairment in multiple sclerosis. J Neurol Sci. 2016;361:200-3.
  • Andreasen AK, Iversen P, Marstrand L, Siersma V, Siebner HR, Sellebjerg F. Structural and cognitive correlates of fatigue in progressive multiple sclerosis. Neurol Res. 2019;41:168-176.
  • Johansson S, Ytterberg C, Hillert J, Widén Holmqvist L, Von Koch L. A longitudinal study of variations in and predictors of fatigue in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79:454-7.
  • Wood B, Van Der Mei IA, Ponsonby AL, Pittas F, Quinn S, Dwyer T et al. Prevalence and concurrence of anxiety, depression and fatigue over time in multiple sclerosis. Mult Scler. 2013;19:217-24.
  • Mills RJ, Young CA. The relationship between fatigue and other clinical features of multiple sclerosis. Mult Scler. 2011;17:604-12.
  • Langeskov-Christensen M, Bisson EJ, Finlayson ML, Dalgas U. Potential pathophysiological pathways that can explain the positive effects of exercise on fatigue in multiple sclerosis: a scoping review. J Neurol Sci. 2017;373:307-20.
  • Rooney S, Wood L, Moffat F, Paul L. Prevalence of fatigue and its association with clinical features in progressive and non-progressive forms of multiple sclerosis. Mult Scler Relat Disord. 2019;28:276-82.
  • Niino M, Mifune N, Kohriyama T, Mori M, Ohashi T, Kawachi I et al. Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis. BMC Neurol. 2014;14:3.
  • Biberacher V, Schmidt P, Selter RC, Pernpeinter V, Kowarik MC, Knier B et al. Fatigue in multiple sclerosis: associations with clinical, mri and csf parameters. Mult Scler. 2018;24:1115-25.
  • Iriarte J, Subirá ML, Castro P. Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors. Mult Scler. 2000;6:124-30.
  • Herring TE, Alschuler KN, Knowles LM, Phillips KM, Morean WM, Turner AP et al. Differences in correlates of fatigue between relapsing and progressive forms of multiple sclerosis. Mult Scler Relat Disord. 2021;54:103109.
  • Rosti-Otajärvi E, Hämäläinen P. Behavioural symptoms and impairments in multiple sclerosis: a systematic review and meta-analysis. Mult Scler. 2013;19:31-45.
  • De Paepe AE, Sierpowska J, Garcia-Gorro C, Martinez-Horta S, Perez-Perez J, Kulisevsky J et al. White matter cortico-striatal tracts predict apathy subtypes in Huntington's disease. Neuroimage Clin. 2019;24:101965.
  • Figved N, Benedict R, Klevan G, Myhr KM, Nyland HI, Landrø NI et al. Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis. Mult Scler. 2008;14:1084-90.
  • Lester K, Stepleman L, Hughes M. The association of illness severity, self-reported cognitive impairment, and perceived illness management with depression and anxiety in a multiple sclerosis clinic population. J Behav Med. 2007;30:177-86.
  • Patti F, Amato MP, Trojano M, Bastianello S, Tola MR, Goretti B et al. Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the cognitive impairment in multiple sclerosis (COGIMUS) study. Mult Scler. 2009;15:779-88.
There are 38 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Ozge Gonul Oner 0000-0003-4199-442X

Ozlem Totuk 0000-0001-7274-025X

İpek Gungor Dogan This is me 0000-0002-8667-9119

Didem Celik This is me 0000-0002-4895-3041

Serkan Demir 0000-0003-4395-5141

Publication Date March 31, 2022
Acceptance Date January 24, 2022
Published in Issue Year 2022 Volume: 47 Issue: 1

Cite

MLA Gonul Oner, Ozge et al. “Evaluation of Neuropsychiatric Symptoms in Patients With Multiple Sclerosis”. Cukurova Medical Journal, vol. 47, no. 1, 2022, pp. 208-1, doi:10.17826/cumj.1018632.