Research Article
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Kronik Gerilim Tipi Baş Ağrısı Profilaksisinde Amitriptilin ve Essitolopramın Karşılaştırılması

Year 2023, Volume: 1 Issue: 3, 92 - 96, 31.10.2023

Abstract

Amaç: Kronik gerilim tipi baş ağrısının profilaktik tedavisinde amitriptilin ve essitalopram kullanımının ağrı skorlaması, ağrılı gün sayısı ve ağrı kesici kullanımı üzerine etkilerini karşılaştırmayı amaçladık. Gereç ve Yöntem: Kronik gerilim tipi baş ağrısı tanılı 51 amitriptilin ve 42 essitalopram profilaksisi alan toplam 93 hasta çalışmaya alındı. Depresyon ekarte edilen hastalar, 3 aylık profilaksi sonucunda ağrı skorlamalarında, ağrılı gün sayılarında ve ağrı kesici kullanım sayılarındaki değişimler yönünden karşılaştırıldı. Bulgular: Amitriptilin essitalopramla kıyaslandığında vizüel analog skala skorlamasında ve 3 aylık Hamilton depresyon ölçeği skorlamasında anlamlı fark yaratmıştır (p=0,027 ve p=0,007). Ağrılı gün sayısı ve ağrı kesici kullanım sıklığı açısından iki grup arasında anlamlı fark bulunmadı (p=0,229 ve p=0,672). Sonuç: Kronik gerilim tipi baş ağrısı toplumda en fazla görülen baş ağrısı tipidir. Profilaktik tedavisinde ilk seçenek amitriptilin olmakla birlikte geniş yan tesir profili ve yaşlılar gibi özellikli gruplarda kullanım kısıtlılıkları sebebiyle alternatif ajanlara ihtiyaç vardır. Bu çalışmada essitalopramın toplumumuzda profilaktik olarak kullanılma ihtimalini ortaya koymuştur.

Ethical Statement

ekte bildirilmiştir.

Supporting Institution

yoktur

Project Number

2023-19

References

  • Stovner LJ, Hagen K, Linde M, Steiner TJJTjoh, pain. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. 2022;23(1):34.
  • Ertas M, Baykan B, Kocasoy Orhan E, Zarifoglu M, Karli N, Saip S, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. 2012;13(2):147-57.
  • Jensen RHJHTJoH, Pain F. Tension‐type headache–the normal and most prevalent headache. 2018;58(2):339-45.
  • Bigal ME, Tepper SJ, Sheftell FD, Rapoport AM, Lipton RBJHTJoH, Pain F. Chronic daily headache: correlation between the 2004 and the 1988 International Headache Society diagnostic criteria. 2004;44(7):684-91.
  • Ashina M, Bendtsen L, Jensen R, Sakai F, Olesen JJP. Muscle hardness in patients with chronic tension-type headache: relation to actual headache state. 1999;79(2-3):201-5.
  • Wittrock DAJHTJoH, Pain F. The comparison of individuals with tension‐type headache and headache‐free controls on frontal EMG levels: a meta‐analysis. 1997;37(7):424-32.
  • Bendtsen L, Evers S, Linde M, Mitsikostas D, Sandrini G, Schoenen JJEjon. EFNS guideline on the treatment of tension‐type headache–Report of an EFNS task force. 2010;17(11):1318-25.
  • Jackson JL, Mancuso JM, Nickoloff S, Bernstein R, Kay CJJogim. Tricyclic and tetracyclic antidepressants for the prevention of frequent episodic or chronic tension-type headache in adults: a systematic review and meta-analysis. 2017;32:1351-8.
  • Tarlaci SJCn. Escitalopram and venlafaxine for the prophylaxis of migraine headache without mood disorders. 2009;32(5):254-8.
  • Burch RJMC. Migraine and tension-type headache: diagnosis and treatment. 2019;103(2):215-33.
  • Burch RJCtoin. Antidepressants for preventive treatment of migraine. 2019;21:1-12.
  • Dhillon S, Scott LJ, Plosker GLJCd. Escitalopram: a review of its use in the management of anxiety disorders. 2006;20:763-90.
  • Shimizu TJB, Shinpo NSKn. Headache and Vertigo. 2020;72(4):303-9.
  • Alagöz AN, Şirin S, Bünül SDJKTD. Gerilim tipi baş ağrısı hastalarında temporomandibular disfonksiyon birlikteliği. 2020;9(3):79-85.
  • Yu S, Han XJCp, reports h. Update of chronic tension-type headache. 2015;19:1-8.
  • Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. 2007;27(3):193-210.
  • Fumal A, Schoenen JJTLN. Tension-type headache: current research and clinical management. 2008;7(1):70-83.
  • Torrente Castells E, Vázquez Delgado E, Gay Escoda CJMO, Patología Oral y Cirugia Bucal, , vol. 13, num. 9, p. 567-572. Use of amitriptyline for the treatment of chronic tension-type headache. Review of the literature. 2008.
  • Exposto FG, Bendixen KH, Ernberg M, Bach FW, Svensson PJC. Characterization and predictive mechanisms of experimentally induced tension-type headache. 2019;39(10):1207-18.
  • Starling AJ, editor Diagnosis and management of headache in older adults. Mayo Clinic Proceedings; 2018: Elsevier.
  • Palacios-Ceña M, Wang K, Castaldo M, Ordás-Bandera C, Torelli P, Arendt-Nielsen L, et al. Variables associated with the use of prophylactic amitriptyline treatment in patients with tension-type headache. 2019;35(4):315-20.
  • Taylor FRJU, mayo. Tension-type headache in adults: Preventive treatment. 2015.
  • Zissis N, Harmoussi S, Vlaikidis N, Mitsikostas D, Thomaidis T, Georgiadis G, et al. A randomized, double-blind, placebo-controlled study of venlafaxine XR in out-patients with tension-type headache. 2007;27(4):315-24.
  • Lampl C, Marecek S, May A, Bendtsen LJC. A prospective, open-label, long-term study of the efficacy and tolerability of topiramate in the prophylaxis of chronic tension-type headache. 2006;26(10):1203-8.
  • Fogelholm R, Murros KJHTJoH, Pain F. Tizanidine in chronic tension‐type headache: A placebo controlled double‐blind cross‐over study. 1992;32(10):509-13.
  • Murros K, Kataja M, Hedman C, Havanka H, Säkö E, Färkkilä M, et al. Modified‐release formulation of tizanidine in chronic tension‐type headache. 2000;40(8):633-7.
  • Bettucci D, Testa L, Calzoni S, Mantegazza P, Viana M, Monaco FJTjoh, et al. Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension–type headache: evaluation of efficacy and impact on quality of life. 2006;7:34-6.
  • Martin-Araguz A, Bustamante-Martinez C, de Pedro-Pijoán JJRdN. Treatment of chronic tension type headache with mirtazapine and amitriptyline. 2003;37(2):101-5.
  • Bendtsen L, Buchgreitz L, Ashina S, Jensen RJEjon. Combination of low‐dose mirtazapine and ibuprofen for prophylaxis of chronic tension‐type headache. 2007;14(2):187-93.
  • Bendtsen L, Jensen RJN. Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. 2004;62(10):1706-11.
  • Bendtsen L, Jensen R, Olesen JJJoN, Neurosurgery, Psychiatry. A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. 1996;61(3):285-90.
  • Singh N, Misra SJTJotAoPoI. Sertraline in chronic tension-type headache. 2002;50:873-8.
  • Muthmainnina AN, Kurniawan SNJJoP, Headache, Vertigo. TENSION TYPE HEADACHE (TTH). 2022;3(2):41-4.
  • Banzi R, Cusi C, Randazzo C, Sterzi R, Tedesco D, Moja L, et al. Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of tension‐type headache in adults. 1996;2019(11).
  • Banzi R, Cusi C, Randazzo C, Sterzi R, Tedesco D, Moja LJCDoSR. Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in adults. 2015(4).
  • Abu Bakar N, Tanprawate S, Lambru G, Torkamani M, Jahanshahi M, Matharu MJC. Quality of life in primary headache disorders: a review. 2016;36(1):67-91.

Comparison of Amitriptyline and Escitalopram in Tension-Type Headache Prophylaxis

Year 2023, Volume: 1 Issue: 3, 92 - 96, 31.10.2023

Abstract

Aim: We aimed to compare the effects of amitriptyline and escitalopram use in the prophylactic treatment of chronic tension-type headache on pain scoring, number of painful days, and painkiller use. Material and Method: A total of 93 patients diagnosed with chronic tension-type headache, 51 receiving amitriptyline and 42 receiving escitalopram prophylaxis, were included in the study. Patients in whom depression was ruled out were compared in terms of changes in pain scores, number of days with pain, and number of painkillers used as a result of 3-month prophylaxis. Results: Amitriptyline caused a statistically significant difference in visual analogue scale scoring and 3-month Hamilton depression scale scoring when compared to escitalopram (p=0.027 and p=0.007). There was no significant difference between the two groups in terms of the number of painful days and the frequency of painkiller use (p=0.229 and p=0.672). Conclusion: Chronic tension-type headache is the most common type of headache in society. Although amitriptyline is the first choice in prophylactic treatment, alternative agents are needed due to its wide side effect profile and limitations in use in special groups such as the elderly. This study revealed the possibility of using escitalopram prophylactically in our society.

Project Number

2023-19

References

  • Stovner LJ, Hagen K, Linde M, Steiner TJJTjoh, pain. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. 2022;23(1):34.
  • Ertas M, Baykan B, Kocasoy Orhan E, Zarifoglu M, Karli N, Saip S, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults. 2012;13(2):147-57.
  • Jensen RHJHTJoH, Pain F. Tension‐type headache–the normal and most prevalent headache. 2018;58(2):339-45.
  • Bigal ME, Tepper SJ, Sheftell FD, Rapoport AM, Lipton RBJHTJoH, Pain F. Chronic daily headache: correlation between the 2004 and the 1988 International Headache Society diagnostic criteria. 2004;44(7):684-91.
  • Ashina M, Bendtsen L, Jensen R, Sakai F, Olesen JJP. Muscle hardness in patients with chronic tension-type headache: relation to actual headache state. 1999;79(2-3):201-5.
  • Wittrock DAJHTJoH, Pain F. The comparison of individuals with tension‐type headache and headache‐free controls on frontal EMG levels: a meta‐analysis. 1997;37(7):424-32.
  • Bendtsen L, Evers S, Linde M, Mitsikostas D, Sandrini G, Schoenen JJEjon. EFNS guideline on the treatment of tension‐type headache–Report of an EFNS task force. 2010;17(11):1318-25.
  • Jackson JL, Mancuso JM, Nickoloff S, Bernstein R, Kay CJJogim. Tricyclic and tetracyclic antidepressants for the prevention of frequent episodic or chronic tension-type headache in adults: a systematic review and meta-analysis. 2017;32:1351-8.
  • Tarlaci SJCn. Escitalopram and venlafaxine for the prophylaxis of migraine headache without mood disorders. 2009;32(5):254-8.
  • Burch RJMC. Migraine and tension-type headache: diagnosis and treatment. 2019;103(2):215-33.
  • Burch RJCtoin. Antidepressants for preventive treatment of migraine. 2019;21:1-12.
  • Dhillon S, Scott LJ, Plosker GLJCd. Escitalopram: a review of its use in the management of anxiety disorders. 2006;20:763-90.
  • Shimizu TJB, Shinpo NSKn. Headache and Vertigo. 2020;72(4):303-9.
  • Alagöz AN, Şirin S, Bünül SDJKTD. Gerilim tipi baş ağrısı hastalarında temporomandibular disfonksiyon birlikteliği. 2020;9(3):79-85.
  • Yu S, Han XJCp, reports h. Update of chronic tension-type headache. 2015;19:1-8.
  • Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. 2007;27(3):193-210.
  • Fumal A, Schoenen JJTLN. Tension-type headache: current research and clinical management. 2008;7(1):70-83.
  • Torrente Castells E, Vázquez Delgado E, Gay Escoda CJMO, Patología Oral y Cirugia Bucal, , vol. 13, num. 9, p. 567-572. Use of amitriptyline for the treatment of chronic tension-type headache. Review of the literature. 2008.
  • Exposto FG, Bendixen KH, Ernberg M, Bach FW, Svensson PJC. Characterization and predictive mechanisms of experimentally induced tension-type headache. 2019;39(10):1207-18.
  • Starling AJ, editor Diagnosis and management of headache in older adults. Mayo Clinic Proceedings; 2018: Elsevier.
  • Palacios-Ceña M, Wang K, Castaldo M, Ordás-Bandera C, Torelli P, Arendt-Nielsen L, et al. Variables associated with the use of prophylactic amitriptyline treatment in patients with tension-type headache. 2019;35(4):315-20.
  • Taylor FRJU, mayo. Tension-type headache in adults: Preventive treatment. 2015.
  • Zissis N, Harmoussi S, Vlaikidis N, Mitsikostas D, Thomaidis T, Georgiadis G, et al. A randomized, double-blind, placebo-controlled study of venlafaxine XR in out-patients with tension-type headache. 2007;27(4):315-24.
  • Lampl C, Marecek S, May A, Bendtsen LJC. A prospective, open-label, long-term study of the efficacy and tolerability of topiramate in the prophylaxis of chronic tension-type headache. 2006;26(10):1203-8.
  • Fogelholm R, Murros KJHTJoH, Pain F. Tizanidine in chronic tension‐type headache: A placebo controlled double‐blind cross‐over study. 1992;32(10):509-13.
  • Murros K, Kataja M, Hedman C, Havanka H, Säkö E, Färkkilä M, et al. Modified‐release formulation of tizanidine in chronic tension‐type headache. 2000;40(8):633-7.
  • Bettucci D, Testa L, Calzoni S, Mantegazza P, Viana M, Monaco FJTjoh, et al. Combination of tizanidine and amitriptyline in the prophylaxis of chronic tension–type headache: evaluation of efficacy and impact on quality of life. 2006;7:34-6.
  • Martin-Araguz A, Bustamante-Martinez C, de Pedro-Pijoán JJRdN. Treatment of chronic tension type headache with mirtazapine and amitriptyline. 2003;37(2):101-5.
  • Bendtsen L, Buchgreitz L, Ashina S, Jensen RJEjon. Combination of low‐dose mirtazapine and ibuprofen for prophylaxis of chronic tension‐type headache. 2007;14(2):187-93.
  • Bendtsen L, Jensen RJN. Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. 2004;62(10):1706-11.
  • Bendtsen L, Jensen R, Olesen JJJoN, Neurosurgery, Psychiatry. A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache. 1996;61(3):285-90.
  • Singh N, Misra SJTJotAoPoI. Sertraline in chronic tension-type headache. 2002;50:873-8.
  • Muthmainnina AN, Kurniawan SNJJoP, Headache, Vertigo. TENSION TYPE HEADACHE (TTH). 2022;3(2):41-4.
  • Banzi R, Cusi C, Randazzo C, Sterzi R, Tedesco D, Moja L, et al. Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of tension‐type headache in adults. 1996;2019(11).
  • Banzi R, Cusi C, Randazzo C, Sterzi R, Tedesco D, Moja LJCDoSR. Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in adults. 2015(4).
  • Abu Bakar N, Tanprawate S, Lambru G, Torkamani M, Jahanshahi M, Matharu MJC. Quality of life in primary headache disorders: a review. 2016;36(1):67-91.
There are 36 citations in total.

Details

Primary Language Turkish
Subjects Neurology and Neuromuscular Diseases
Journal Section Research Article
Authors

Gökhan Evcili 0000-0003-2965-9936

Aykut Öztürk 0000-0003-4515-6968

Project Number 2023-19
Publication Date October 31, 2023
Submission Date September 25, 2023
Published in Issue Year 2023 Volume: 1 Issue: 3

Cite

AMA Evcili G, Öztürk A. Kronik Gerilim Tipi Baş Ağrısı Profilaksisinde Amitriptilin ve Essitolopramın Karşılaştırılması. Ağrı Med J. October 2023;1(3):92-96.